University of Wisconsin - Madison

Position Vacancy Listing

PVL # 226665

Position Summary:
The Biology of Aging research program focuses on genetic, molecular and cellular mechanisms that make aging one of the greatest risk factors for nearly every chronic disease. The anti-diabetic drug metformin can delay the onset of several age-related diseases in animals. Retrospective data suggests metformin increases survival in patients with type 2 diabetes. However, it remains to be determined if metformin can increase indices of healthy longevity in non-diabetic adults. A research specialist is needed to activate and coordinate studies using metformin and/or other interventions (e.g., exercise, diet, etc.). These studies will include gold-standard techniques to evaluate insulin sensitivity, glucose regulation, skeletal muscle mitochondrial remodeling and function, and biomarkers of aging. This position will work in the lab of Dr. Adam Konopka and assist with growing a new translational research program.

The School of Medicine and Public Health, and the Division of Geriatrics and Gerontology have a deep and profound commitment to diversity both as an end in itself, but also as a valuable means for eliminating health disparities. As such, we strongly encourage applications from candidates who foster and promote the values of diversity and inclusion.

Principal duties:
Recruitment and Retention (30%)
- Implement recruitment strategies and follow up with research participants and potential participants
- Collect medical records to support eligibility determinations
- Assist with determining eligibility for study drug intervention and invasive procedures, including oral metformin, intravenous infusions, and skeletal muscle biopsies. Review potential risks.
- Schedule, communicate, and coordinate study visits with participants, study personnel and other units

Study visits (30%)
- Conduct informed consent process
- Ensure participants' safety in all study procedures
- Place continuous glucose monitors on eligible participants and review proper care
- Prepare participants for DEXA scans
- Perform hyperinsulinemic-euglycemic clamps to assess insulin sensitivity
- Assist with skeletal muscle biopsies
- Organize and maintain research records

Regulatory, Operations, and Data (25%)
- Prepare IRB submissions
- Assist with data safety monitoring and study compliance
- Coordinate with other working groups such as the UWHC Clinical Research Unit (CRU) to implement and maintain studies
- Perform data entry and manage database
- Prepare and update sample and supply organization and inventory
- Assist with internal SOP development and maintenance.
- Assist with onboarding new personnel
- Perform training for good clinical practices for all study personnel
- Ensure all necessary training for study team is completed and maintained

Other duties (15%)
- Disseminate research information to the general public. Work with community stakeholders to present educational, engagement, and recruitment material to populations who will benefit most from ongoing aging research studies in the Biology of Aging program and the Division of Geriatrics and Gerontology.
- Work with the research program manager to maintain study budgets; make lab purchases and submit subject payments
- Perform other related duties as assigned

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